A randomized, double-blind, placebo-controlled trial

J. Piatkowski, M. D., S. Kern, Ph. D. and T. Ziemssen, M. D., The Journal of alternative and complementary medicine, 2009

Objective: Electromagnetic field therapy has been reported to be beneficial in patients with multiple sclerosis (MS) with significant fatigue. This study was designed to evaluate the long-term effects of Bio-Electro-Magnetic-Energy-Regulation (BEMER) on MS-related fatigue. Patients: There were 37 relapsing-remitting patients with MS with significant fatigue. The intervention consisted of BEMER magnetic field treatment for 8 minutes twice a day, in comparison to a placebo for 12 weeks. Outcome measures: The primary outcome criterion was a change in the Modified Fatigue Impact Scale (MFIS) between the baseline and 12 weeks. The secondary outcome criteria were changes in the Fatigue Severity Scale (FSS), a general depression scale-long version (ADS-L), Multiple Sclerosis Functional Scale (MSFC), and the Expanded Disability Status Scale (EDSS). Results: There was evidence of a significant difference in the MFIS value (primary outcome criterion) after 12 weeks in favor of the verum group (26.84 versus 36.67; p = 0.024). In addition, FSS values were significantly lower in the verum group after 12 weeks (3.5 versus 4.7; p = 0.016). At a follow-up after 6 weeks, the verum and placebo groups did not differ in experienced fatigue (MFIS, FSS). Regarding the subscales of the MFIS, there was a significant decrease in the physical (p = 0.018) and cognitive (p = 0.041), but not in the psychological subscale – in the verum group. The BEMER therapy was well tolerated.

Conclusion: In this pilot study, we were able to demonstrate the beneficial effect of a BEMER intervention onmultiple sclerosis fatigue Multiple sclerosis and magnetic therapy.

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